Impact of Xeomin, Dysport and Botox on Nerve Injuries

Background: The proposed research aims to investigate the effect of Dysport, Botox, and Xeomin on peripheral nerves. We hypothesize that injection of these neuromodulators may induce some degree of peripheral nerve injury. While these neuromodulators are widely used for their ability to paralyze targeted muscle groups temporarily, their direct impact when injected into nerves remains poorly understood. Given the widespread use of these injectables and the existing gaps in research, a thorough investigation is essential to assess their potential for causing nerve damage and subsequent patient morbidity.

The primary objective of this study is to evaluate the effects of neuromodulators on peripheral nerves to optimize patient safety. Using an animal model, we will meticulously examine and quantify the extent of sural nerve damage associated with Dysport, Botox, and Xeomin injections. Additionally, we aim to identify the specific types of nerve damage each neurotoxin may cause and compare their respective impacts. This comparative analysis will provide valuable insights into the distinct risk profiles of each neurotoxin.

As the use of neuromodulators continues to rise, understanding their potential adverse effects on nearby nerves is crucial for patient safety. The findings from this study aim to enhance injector education and improve patient outcomes through more informed and responsible use of these treatments.